A new isoprostane method for application in early diagnosis of inflammatory diseases

Diarienummer 2015-04914
Koordinator Umeå universitet - Kemiska Institutionen
Bidrag från Vinnova 828 563 kronor
Projektets löptid januari 2016 - juni 2018
Status Avslutat
Ansökningsomgång VINNMER Marie Curie Academy Outgoing 2015-09-16

Syfte och mål

We established a new method for isoprostanes and its related metabolites, validated it in a murine model and applied it for two population studies. Moreover, such method is planning to develop into a related product for assessing the inflammatory status in physical examination for health/subhealth population.

Resultat och förväntade effekter

The outcome of this project is 1) developed a robust method for detection of isoprostane and its related biomarkers of inflammatory conditions at an early stage and finalized a SOP for high throughput measurement; 2) validated and applied this method to animal model and human pilot studies; 3) adapted such method to a product that monitor inflammatory status based on such targeted functional metabolites in health population.

Upplägg och genomförande

This project was a follow-up on previous planning grant that all collaborators from three parties have already discussed the feasibility and defined the subsidiary goals. The implementation of this project was carried out according to half/half workload in Sweden and China in the past 2.5 years. Even the project changed slightly revised due to the pregnancy of the project leader in the last six months, but the progress keep the same after coordinated with the each party. We finalized the SOP for high throughout measurement that might benefit for Swedish and Chinese markets.

Externa länkar

Metabolomic service for public to detect the isoprostane and other eicosanoids by targeted quantitative analysis.

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