Th-17-signalering och polarisering av alveolära makrofager vid kroniskt obstruktiv lungsjukdom

Diarienummer 2016-01951
Koordinator Karolinska Institutet - Institutet för miljömedicin
Bidrag från Vinnova 2 115 337 kronor
Projektets löptid juli 2016 - december 2018
Status Beslutat

Syfte och mål

The scientific content and career development plan of the program is designed to offer Dr. Koustav Ganguly experience in human cohort studies and utilize his expertise in genetics and mouse models of lung to the translational research platform in the host unit. Dr Ganguly´s international research collaborations and our established national and international research network would result in unique competence. The overall aim of the program is to enable Dr. Ganguly to attain professional maturity and take his career to the next level and establish his research group at the host unit.

Förväntade effekter och resultat

Successful completion of the program would lead to the identification of key Th17-signaling molecules determining alveolar macrophage polarization in chronic obstructive pulmonary disease (COPD) and establishment of Dr. Ganguly as an independent researcher in the host unit. The scientific findings are aimed for lead target discovery to influence macrophage heterogeneity for evolving novel therapeutic strategies in COPD. The defined program addresses the future research areas of European respiratory roadmap, namely: Lung and the Environment & Early Origins of Lung Disease.

Planerat upplägg och genomförande

To achieve the scientific objectives of the program, well characterized subphenotypes of COPD cohort and molecular assessment involving three different body compartments namely, bronchoalveolar space, alveolar wall and blood will be performed thereby providing a robust physiological platform to the study. Moreover, a carefully designed structured career outline has been formulated for Dr. Ganguly towards establishment as an independent scientist at the host unit, an important step for which will be attainment of ´docentur´ in research track by the completion of this program.

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