Early diagnosis of coloncancer
|Coordinator||AB MAvatar - Cellbiologen|
|Funding from Vinnova||SEK 220 397|
|Project duration||June 2018 - July 2019|
Purpose and goal
Colorectal cancer (CRC) is the third most common cancer. Because the prognosis is due to early diagnostics, a safe diagnostic test is needed. With the help of Vinnova, we have developed a combination test for CRC, ColoTest, where the analysis of four different protein concentrations in a blood sample is weighed together using an algorithm. We have applied for a patent for ColoTest and are now negotiating with a diagnostic company to develop ColoTest for clinical use.
Expected results and effects
We have achieved the goal of the application, namely the development of a test for early CRC diagnostics, ColoTest, which is based on analyzing four proteins in blood samples, and to classify diagnostically using an algorithm. We have applied for a patent for ColoTest and are negotiating with a diagnostic company to develop this.
Planned approach and implementation
We have analyzed thousands of mRNAs and proteins in already completed studies of CRC. With the help of the computer, we have sorted out nine proteins that seemed to be especially good for diagnostics. We tested these nine proteins in blood samples from a hundred patients and matched controls. We found that four proteins separated patients from controls with high accuracy. This was done with a classification algorithm that will be developed into a user-friendly diagnostic tool, as part of the ColoTest.