Multimodal visualization of the microcirculation

Purpose and goal

The project aims to develop and evaluate a system for imaging the blood flow and oxygenation in skin microcirculation with sufficient spatial and temporal resolution for clinical use. The technique has been developed to provide real time feedback to the surgeon during an endovascular intervention for determine if further angioplasty of obstructed vessels is necessary. The work has resulted in a proof-of-concept prototype in accordance with the project objectives.

Expected results and effects

The proposed prototype combines two imaging techniques for real time measurement of blood flow and oxygenation in the same tissue area. A pilot study in the clinical environment shows that the technique is well suited for use during surgery. With proposed analysis algorithms, image data can be analyzed in real time, allowing for a technical solution where the surgeon can directly receive feedback during an endovascular intervention.

Planned approach and implementation

The project has been carried out in collaboration between Linköping University, Perimed AB and Region Östergötland. The broad competence of the group has made it possible to design and construct an imaging system and to prepare clinical trials. The project has faced major technological challenges and at present, single image sequences can be collected and analyzed. The results are very promising and highlight the technology´s future ability to improve the endovascular intervention procedure.