Eurostars Project E!10960, CellSenseGels, Attana AB: Developing sensitive and robust cell-based biosensor assays using gel matrices
|Funding from Vinnova
|SEK 2 682 641
|May 2017 - April 2019
Purpose and goal
CellSenseGels aimed to make a new Product combining peptide gel matrices of BiogelX with Attana´s biosensor technology to increase the capabilities of Attana´s unique ability to measure the kinetics of molecular interactions as they take place on cell Surfaces. The sensitivity of measuring small molecules in biochemical assays increased and the biological relevance in cell based measurements was increased and developed by successful incorporation of cells into the gel.
Expected results and effects
The consortium expects to expand on the ability to measure a wider spectrum of molecules and measure it in a more biological relevant environment. The market for both BiogelX and Attana was expected to increase thankts to introducing the application to drug development companies. The Project increased the Attana´s application portfolio by adding the new type of surface matrix platform suitable for small molecules and increase biological relevance for measuring interactions with cells.
Planned approach and implementation
The project plan contains 4 work packages covering e.g. compatibility measurements, measurements of a wide range of molecules and a between-labs comparison. Attana provided biosensing expertise, BiogelX brought peptide gel matrix knowledge and University of Stuttgart provided cellular and biochemical know-how. The work package 1, 2 and 4 were concluded while work package 3 was delayed due to further optimization of gel matrix rigidity is needed.