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E!114244, Blue4Therapy, AcouSort

Reference number
Coordinator AcouSort AB - AcouSort AB Medicon Village
Funding from Vinnova SEK 3 108 500
Project duration September 2020 - April 2023
Status Completed
Venture Eurostars

Purpose and goal

The use of ADRC (adipose derived regenerative cells) is a promising strategy for regenerative therapy. The number of BlueCells (CD31+ cells) present at low concentrations in ADRC samples has been shown to correlate positively with treatment efficacy. Within the project, a BlueSORT machine has been developed and manufactured that can separate BlueCells from ADRC samples using ultrasound. A cartridge for a single-use separation module has been developed and the machine together with the cartridge has been successfully tested with patient samples.

Expected effects and result

The isolation of ADRC from adipose tissue samples could be quadrupled after the optimization of the standard protocol. A method using ultrasound to separate BlueCells from ADRC samples has been developed and successfully tested with patient samples. Manufacturing of a BlueSORT machine with consumables, developed within the project, makes it possible to have a reliable and reproducible purification of BlueCells for research and clinical treatment. Further studies will demonstrate the effectiveness of purified BlueCells for use in regenerative therapy.

Planned approach and implementation

nterviews with relevant customers/users were performed in the beginning of the project to gather requirements related to performance, functionality, and safety of a BlueSORT platform. The outcome of the interviews was used as input and guidance for the different work packages. Close collaboration between the partners was kept during the project. A steering group was formed, and the project progress was discussed in regular consortium meetings.

The project description has been provided by the project members themselves and the text has not been looked at by our editors.

Last updated 30 June 2023

Reference number 2020-03356

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