Ultrasound-based arterial strain imaging for improved detection of cardiovascular diseases

Purpose and goal

The goal was to develop, validate and test non-invasive ultrasound-based techniques to improve early detection of arterial stiffness and characterization of atherosclerotic plaques. The techniques have been developed and validated experimentally and in animal models and tested successfully in-vivo through close collaboration between KTH and KU Leuven. The VINNMER fellow has during the project been admitted to Tenure Track at KTH which provides good opportunities for development as a research leader.

Results and expected effects

The project has resulted in ultrasound-based methods for estimating elasticity of the arterial wall and atherosclerotic plaques. The methods have been thoroughly validated and tested in clinical applications with promising results. The methods were demonstrated to be sensitive to detect arterial plaque and wall stiffness. The new methods have great potential to improve diagnostics of cardiovascular disease and be of benefit to patients in the form of refined and less invasive diagnostics, which in turn results in decreased mortality and a more cost-effective medical care.

Approach and implementation

The project was implemented with a close exchange between KTH and KU Leuven, with several involved researchers from both institutions to strengthen the long-term collaboration. During the first part of the project, the methods were developed and adapted for measurements in vascular tissue. Thereafter, validation setups both in-vitro and in-vivo were constructed with focus on reliable reference methods. The results from the in-vitro tests were then used to optimize the signal processing prior to the in-vivo studies.