Exosomes as delivery vectors for polypeptide therapeutics for the treatment of inflammatory diseases

Purpose and goal

The overall goal of the project was to develop a comprehensive business strategy as well as to deliver an investment package for the future spin off company. The product is a polypeptide displayed on exosomes that binds inflammation enhancing molecules. Within the project questions regarding technical and commercial interests was evaluated in order to be increase production and isolation of the product as well as to enhance the anti-inflammatory properties. Furthermore, market and IP analysis was performed.

Expected results and effects

The aim was to commercialize exosomes as a delivery vector for anti-inflammatory drugs. The product and the production of the product were improved. The analysis of the market- and IP-landscape revealed a growing market where we had freedom to operate with our product. During the project period a collaboration with Oxford University was initiated which resulted in a wider IP portfolio with increased interest from outside investors. The collaborative effort resulted in a spin off company called EvOx Therapeutics Ltd.

Planned approach and implementation

Within the project questions of technical and commercial nature were investigated to enhance the production, isolation and the anti-inflammatory activity of the product. During the project all these parameters were improved, however there is still room for further refinement. Furthermore, IP and market analysis was performed to evaluate the commercialisation potential of the project. The subsequent results were an important segment in the large interest the spin off company generated from investors.