Challenges in the development of a detector with high sensitivity for the evaluation of biological processes

Purpose and goal

Biocrine aims to be able to study cellular processes in a living organism, while it is awake, by developing a contact lens with an integrated fluorescence measurement system. The goal of this project was to evaluate a) a possibility to develop a detector sensitive enough to read fluorescence from cells, and b) how excitation should be so that cells are not damaged. The goals were reached: Excitation parameters were studied and already existing detectors are sensitive enough so that they can be developed towards set performance with reasonable effort in the next stage of work.

Results and expected effects

Project results are very positive. The main delivery of the project is experimental data that both verifies and quantifies the initial estimates that formed basis for the long-term product development. The outcome suggests that we now can proceed to next stages of development. They will include optimization and miniaturization of light source, detectors and supporting electronics, as well as their integration on a contact lens.

Approach and implementation

The project is interdisciplinary. To reach the set goals, both biology and electronics/optics competences are needed. Biocrine understands molecular and cellular processes associated with diabetes, while Acreo contributes with expertise within electronics/optics. Project set up and implementation have been successful. Open communication has been an important component, with monthly status meetings and more frequent telephone and mail correspondence. Collaboration in a lab has led to meaningful results. Going forward, the groups will collaborate in a similar manner.