Validation of a new antidiabetic food concept targeting the gut microbiota composition

Purpose and goal

The purpose was to develop food products that will contribute to prevention of obesity and type 2 diabetes (T2D). The goal is to launch pre- pro and synbiotic foods documented with beneficial effects on glucose- and appetite regulation up to 14 h after intake. We have successfully developed a prebiotic breakfast prototype with the potential to facilitate glucose and appetite control throughout the day. The product also forms the basis for upcoming syn- and probiotic products, i.e. the inclusion of a potentially new probiotic bacterium (PB) with health benefits on glucose regulation.

Expected results and effects

A tasty breakfast prototype consisting of a dietary fibre-rich milk- and oat-based yogurt with prebiotic barley has been developed, with the potential to improve glucose and appetite regulation during the whole day! Beneficial effects were documented 11-14 hours after intake, linked to increased abundance of the gut PB. It can be expected that intake at breakfast will facilitate metabolic control throughout the day. In mouse models, glucose regulating effects of PB and absence of deleterious effects were verified. The products can be expected to contribute to the prevention of T2D.

Planned approach and implementation

A significant interest and need exist for products with metabolic health benefits. The effects of the breakfast prototype on glucose and appetite control after 11-14 hours were verified in young healthy persons. The product was consumed in the evening, and test variables examined the following morning. An "over-day" study needs to be carried out as proof of concept, and various relevant groups should be addressed. Glucose regulatory- and possibly harmful effects of PB were studied in mice, with good outcome. An important step regarding safety is the detection of PB in ordinary foods.