Utveckling av lungfunktionsensor för förtidigt födda barn baserad på diodlaserspektroskopi

Reference number 2015-04146
Coordinator Lunds universitet - Fysiska Institutionen
Funding from Vinnova SEK 2 079 500
Project duration October 2015 - December 2018
Status Completed
Venture Eurostars
Call Eurostars medfinansiering 2014-2015

Purpose and goal

The aim of this EUROSTARS project was to develop a non-invasive system for monitoring lung function in newborn infants. This new technique is based on the method ´gas in scattering media absorption spectroscopy´ (GASMAS) with a laser source and an absorption detector to be placed on the thoracic skin. The feasibility was evaluated on a phantom and thereafter in an experimental study on newborn piglets. We could detect oxygen and water vapor in normal lungs and robust responses to pulmonary complications. For clinical applications the system was further developed and implemented.

Expected results and effects

In the experimental study, we detected oxygen (wavelength 764 nm) and water vapor (820 nm) from normal lungs and robust changes to the complications (pneumothorax and atelectasis). The equipment was approved to be used in the clinical setting on newborn infants (medicine technique and ethics). The study was performed on 12 healthy newborn infants, who undisturbed slept during assessment.

Planned approach and implementation

The feasibility to monitor newborn infants was verified. The laser light probe and detector were easily attached and patient friendly. The equipment had a laser light source with less power than planned. Therefore we encountered problems due to too low signal/noise ratio and could not detect absorption values reliably in all infants. For future clinical studies the equipment needs to be upgraded with a more intense laser source.

The project description has been provided by the project members themselves and the text has not been looked at by our editors.