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The Toronto Discovery District-an integral Life Science and Technology environment

Reference number
Coordinator Linköpings universitet - Institutionen för fysik, kemi och biologi
Funding from Vinnova SEK 3 000 000
Project duration November 2007 - May 2011
Status Completed

Purpose and goal

- to gain competence in how to build, support and profit from integrated Life Science Technology environments - to learn and implement novel strategies on analysis of folded and disordered proteins by NMR and other biophysical techniques - to learn from female leadership in Science and Medical Biotechnology at highest competitive level.

Results and expected effects

Two research projects form the scientific basis for this program: A) Mothers with the autoimmune disease Sjogren´s syndrome risk fatal heart block in their unborn children. Recent results suggest that impaired E3-ligase activity of Ro52 contributes to the disease. Characterization in molecular detail of the interactions with the Ro52 protein will enable the design of inhibitors and/or enhancers of the disturbed interaction. B) We have recently identified a molecular patch that interacts, and blocks, the oncogenic activity of c-Myc, and are currently investigating its interactions with both tumor enhancers and inhibitors. The urgency of this work is obvious since aggresive c-Myc overexpressing tumors are today largely untreatable.

Approach and implementation

This project includes collaboration and meritation within three internationally top-ranked research groups in the ´Toronto Discovery District´ at the University of Toronto main campus. Methodology implemented in the project mainly includes biophysics and NMR, but also biomedical and cellular techniques.

The project description has been provided by the project members themselves and the text has not been looked at by our editors.

Last updated 25 November 2019

Reference number 2007-01956

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