Sialic Acid Scavenging, Catabolic and Sialylation Pathways: Putative Targets for New Antimicrobial Agents
|Coordinator||Göteborgs Universitet - Inst. för kemi och molekylärbiologi|
|Funding from Vinnova||SEK 5 300 000|
|Project duration||June 2017 - July 2020|
|Venture||Hälsa och sjukdomsprevention - ett samarbete mellan Sverige och Indien|
|Call||Indo-Swedish Innovation Call: Health and Disease Prevention 2017-2020|
Purpose and goal
Antimicrobial resistance poses a major global threat to society. Sialic acids are major cell surface sugars involved in many biological functions. Many pathogenic bacteria use sialic acid as an energy source or incorporate the scavenged sialic acid as the outermost sugar on their surface structures. Incorporation allows them to carry out molecular mimicry, cause sepsis, and survive in biofilms. The catabolic pathway has been shown to be important in GI infections. The project´s contention is that these pathways provide an ideal set of targets for drugs against these pathogenic bacteria.
Expected results and effects
The project group will develop inhibitors of the sialic acid scavenging, catabolic and incorporation pathways present in several pathogenic bacteria with the aim to develop a new class of antimicrobial agents.
Planned approach and implementation
The project group will carry out systems modeling and computing to predict growth curves and druggability, computational docking studies, and structure function studies. Furthermore, the project group will perform medicinal chemistry, organic synthesis and in vitro PK-ADMET studies of a subset of potent and selective compounds.