Sialic Acid Scavenging, Catabolic and Sialylation Pathways: Putative Targets for New Antimicrobial Agents

Reference number 2017-00180
Coordinator Göteborgs Universitet - Inst. för kemi och molekylärbiologi
Funding from Vinnova SEK 5 300 000
Project duration June 2017 - July 2020
Status Ongoing
Venture Hälsa och sjukdomsprevention - ett samarbete mellan Sverige och Indien
Call Indo-Swedish Innovation Call: Health and Disease Prevention 2017-2020

Purpose and goal

Antimicrobial resistance poses a major global threat to society. Sialic acids are major cell surface sugars involved in many biological functions. Many pathogenic bacteria use sialic acid as an energy source or incorporate the scavenged sialic acid as the outermost sugar on their surface structures. Incorporation allows them to carry out molecular mimicry, cause sepsis, and survive in biofilms. The catabolic pathway has been shown to be important in GI infections. The project´s contention is that these pathways provide an ideal set of targets for drugs against these pathogenic bacteria.

Expected results and effects

The project group will develop inhibitors of the sialic acid scavenging, catabolic and incorporation pathways present in several pathogenic bacteria with the aim to develop a new class of antimicrobial agents.

Planned approach and implementation

The project group will carry out systems modeling and computing to predict growth curves and druggability, computational docking studies, and structure function studies. Furthermore, the project group will perform medicinal chemistry, organic synthesis and in vitro PK-ADMET studies of a subset of potent and selective compounds.

The project description has been provided by the project members themselves and the text has not been examined by our editors.