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New technology for preventive cooling therapy against oral mucositis

Reference number
Funding from Vinnova SEK 500 000
Project duration December 2017 - May 2019
Status Completed

Purpose and goal

Regarding the long-term project goal of strongly reducing the presence of oral mucositis as an adverse effect of chemotherapy treatment we have made important progress. Today´s method of cooling with ice has a very poor compliance. Even though our prototype is far from optimal, all test subjects so far who have tested it and ice prefer air cooling. Our results show that air can replace ice as standard treatment for the prevention and easement of mucositis. Air cools in a patient friendly matter without decreased cooling effect.

Expected results and effects

A cooling unit to be used together with a mouth piece has been developed. 20 minutes of cooling with 8-degree air gives an average cooling of the oral cavity with 9.4°C. Ice treatment for 20 minutes gives an average decrease of 10.7°C. Simulations show that cooling with 10-degree air gives a decrease with 15°C and 12°C respectively in the palate and buccal cavity where the air flow is the greatest. This shows that with a better mouth piece with regards to air distribution, it should be possible to get the same cooling effect with air as with ice.

Planned approach and implementation

So far, a cooling unit and several different mouth pieces have been developed. The work to develop an optimal mouth piece with regards to efficient air distribution and being comfortable for a majority of the patients will go on for an extensive period of time. Ethical approval to test the current mouth piece on a larger group of test subjects has been granted. The study will be heavily focused on making sure the product fulfills our concept of control-comfort-distraction.

The project description has been provided by the project members themselves and the text has not been looked at by our editors.

Last updated 20 December 2018

Reference number 2017-04702

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