Identification of novel immunomodulatory targets for cancer immunotherapy

Purpose and goal

There were two main objectives of the project, 1) to establish a methodology on which a new technology platform for identification of novel immunomodulating targets could be based and 2) to identify and characterize immunomodulating target proteins with potential with potential in immunotherapy of cancer.

Expected results and effects

The project resulted in the establishment of a number of experimental methods needed for establishment of a technology platform for identification of immunomodulating proteins. The methods comprise isolation and cultivation of various relevant cell populations as well as analysis of cellular phenotype and function using transcriptomics, flow cytometry and functional analyses. Furthermore, a number of potentially interesting target proteins, which will be characterized further, have been identified.

Planned approach and implementation

The project comprised two sub projects, each using different methods for target protein identification. The two sub projects were divided into well defined work packages and decision points. The aim of this was to prioritize the resources for the sub project with the highest probability of fulfilling the objectives of the project, and, if needed, be able to adjust the project plan. Thereby, the project was conducted in an efficient manner and several of the project objectives were met.