Identification of new treatment options for neuropathology - implementation of a murine stroke model
| Reference number | |
| Coordinator | Karolinska Institutet - Institutionen för medicinsk biokemi och biofysik |
| Funding from Vinnova | SEK 3 000 000 |
| Project duration | December 2011 - December 2016 |
| Status | Completed |
Purpose and goal
The two main goals with the project was to implement a murine model of stroke in the host milieu, for studies of signaling events involved in regulation of barrier permeability during stroke, and for the project leader to further her research and international networking skills to be eligible for an associate professorship (docentur) at the host milieu. These two goals have been reached as the stroke model is now established in the project leaders research group and all requirements for an associate professorship has been fulfilled (docent application has just been completed).
Expected results and effects
During the project the project leader has published nine scientific papers in prestigious journals (many in collaboration with the foreign milieu), completed four additional manuscripts, performed research in the foreign milieu, been invited to international conferences and received funding from eg. VR. Recently a clinical pilot study was publiched showing that inhibition of one of the signaling pathways we have identified leads to clear neurological improvement in stroke patients receiving thrombolytic therapy and the planning for a continuation of these studies are ongoing.
Planned approach and implementation
The project has led to the establishment of a strategically important animal model of stroke and strengthened the collaboration with the foreign milieu. The studies we have published, and continue to work on, has clearly increased the understanding of how blood-brain barrier permeability is regulated and contribute to disease. It is our hope that the results from our studies will lead to better treatment for stroke patients. The project leader has also received important leadership skills and merits during the project to enable an associate professorship in the host milieu.