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High throughput test and procedures for ultra sensitive and accurate chimerism analysis in transplant patients

Reference number
Coordinator Devyser AB
Funding from Vinnova SEK 2 000 000
Project duration February 2018 - January 2019
Status Completed
Venture Innovationsprojekt i företag 2017
Call innovationsprojekt i företag, Hösten 2017

Purpose and goal

The purpose of the project was to develop an NGS-based method for analyzing chimerism after bone marrow transplantation. We have now, at the end of the project, managed to develop such a method for RUO (Research Use Only) use but have also started work on validating the method according to IVDR-CE.

Expected results and effects

We have managed to develop a sensitive method that can detect residual patient cells after a bone marrow transplant down to a level of 0.1%. In addition, the method has good precision both at low and high levels. It would thus be able to replace the commercial methods used today. The method has been tested on labs in Sweden and abroad with great success.

Planned approach and implementation

We have bioinformatically searched for possible genetic markers to be able to distinguish between different individuals. After testing a number of markers, we have found 24 markers that are sufficiently specific and sensitive to be used in the test. In connection with the project, we have also developed a software for calculating and visualizing results.

The project description has been provided by the project members themselves and the text has not been looked at by our editors.

Last updated 6 March 2019

Reference number 2017-04346

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