A nerve repair implant for improvement in quality of life following prostatectomy

Purpose and goal

The goal of this project has been to develop a prototype medical device for peripheral nerve regeneration, with a specific focus on patients treated surgically for prostate cancer. The idea was to, at the end of the project, show an implant with (in animal models) verified desired effect, ready for a first clinical trial. The consortium has come far, and a prototype is developed and successfully evaluated in a rat model. However, there are several more experiments to be made before the implant can be classed as “ready” for studies in man.

Expected results and effects

In vitro we have demonstrated nanofiber induced guidance of neurites from pelvic ganglia for both mouse and rats. An apomorfine/clavulanate based in-vivo model for reestablishing of the erectile function after injury was however not working as described in litteraturen. Hence an alternative model for regeneration of neurites supported by a nanofiber implant to the bladder was tested and histology demonstrated positive nerve regeneration. Next step is a functional model with complete nerve lesion to the bladder to test if the implants may enhance the recovering bladder function.

Planned approach and implementation

The planning has from the start been sound. The implementation has followed the initial project plan well, with the exception for a slightly prolonged business development process, as well as unforeseen problems coupled to the first animal experiments, which has led to the development of an alternative in vivo model. All parts of the project have been continually involved throughout the project, by regular Project meetings and also by being continually updated regarding the practical parts of the Project. Finally, all involved parts are happy with the implementation of the project.