Odling av stamceller på specialdesignad nanofiberbaser matris för tillverkning av extracellulära vesiklar

Important results from the project

The project´s objective has been largely met, however, further optimization and product development is required before a competitive product can be considered ready for market introduction. However, within the framework of the project, adhesion molecules on hematopoietic and mesenchymal stem cells have been successfully characterized, as planned, using single cell RNA sequencing. Nanofibers with peptide ligands for the adhesion molecules identified on the stem cells have also been developed.

Expected long term effects

The results from WP2 will be published in a scientific journal and may contribute to a greater understanding of the interaction of stem cells with the extracellular matrix, which has an impact on stem cell research in a larger context. The results from WP3 are being evaluated at Cellevate, partly from an IP perspective, but also as a basis for continued development work. Much has been learned about the modification of nanofibers, which is of great value for Cellevate´s product development.

Approach and implementation

Our project has been divided into 4 distinct work packages, where one has been dedicated to project management, while the remaining 3 have been of a scientific nature with a lot of iterative development work and strong interactions between each other. The structure was based on previously successfully completed project, and was right for this one also. The schedule was kept with only minor deviations, and the cooperation between the three participating organizations has worked well.