Digitalization of a pharmaceutical lab for process development and pilot production
| Reference number | |
| Coordinator | Lunds universitet - Institutione för Kemiteknik |
| Funding from Vinnova | SEK 5 000 000 |
| Project duration | March 2020 - February 2023 |
| Status | Completed |
| Venture | Strategic innovation programme for process industrial IT and automation – PiiA |
| Call | PiiA: Digitalization of industrial value chains, autumn 2019 |
Important results from the project
The aim was to develop and demonstrate an open, general and modifiable digital platform for the integration of equipment for process development and pilot production of downstream processes for biologics. The project has very successfully demonstrated the concept for a number of cases. The platform´s ability to handle digital solutions has proven successful. Automatic modelling, data management and data storage as well as advanced model-based control have been tested with great success.
Expected long term effects
The main result of the project was the demonstration of a platform for a continuous antibody production. The platform means the automation of multiple systems in networks, which has been studied by industrial parties in the project. The technology, the methodology behind both physical and digital configuration, has been received and further developed by the project´s parties.
Approach and implementation
The project has been implemented as four work packages, work packages 1 to 4. Package 1 focused on the development of an integrated platform for the continuous manufacturing of biological drugs, especially having a process for antibody together with AdBIOPRO. Package 2 focused on digital representation, modeling and simulation, with very promising results. Package 3 integrated automatic data generation and data management with a real-time database. Package 4 studied advanced control of continuous processes.