SMF AdBIOPRO: Identifying Low Affinity IgG Ligands for Continuous LSPR-Based Bioprocess Monitoring

Important results from the project

The project did not fully achieve the main objective of continuous in-process measurement without regeneration. However, an important intermediate milestone was reached by significantly expanding the dynamic measurement range for IgG detection. In addition, the project resulted in new collaborations, methodological developments, and strengthened technical expertise.

Expected long term effects

The project represents an important step toward real-time bioprocess monitoring by improving sensor performance and increasing understanding of long-term operational limitations. The results provide a foundation for further development toward continuous measurement and more efficient biopharmaceutical manufacturing.

Approach and implementation

The project was carried out in collaboration between the company and external research partners and focused on the development and screening of new binders, integration into sensor chips and evaluation of sensor performance in laboratory and process-like conditions. The work was conducted experimentally with ongoing optimization and analysis of results. The project resulted in more academic collaborations instead of with commercial developers of molecular binders.