Innovative Strategy for Targeted Delivery of Precision Medicine Drugs (INSPIRE)
| Reference number | |
| Coordinator | Uppsala Therapeutics AB |
| Funding from Vinnova | SEK 1 918 560 |
| Project duration | May 2021 - April 2023 |
| Status | Completed |
Important results from the project
The aim of the project was to synthesizee chemically modified oligonucleotides that are sensitive to stimuli like alkaline phosphatase and esterase. We have developed esterase-sensitive drug-siRNA conjugates and alkaline-sensitive chemically modified siRNA and DisiRNA.
Expected long term effects
All our siRNAs are functional in invitro condition tested and the results will be published in due course.
Approach and implementation
As designed several chemically modified oligonucleotides which are responsive to stimuli responsive were synthesized and successfully decortaed with drug nanoparticles.A systematic characterization and their funtional properties has been studied.