Individualization of levodopa infusion through objective symptom quantification

Purpose and goal

* Maskinöversatt * The purpose of the project was to investigate whether it is possible in Parkinson´s treatment to replace or supplement the manual subjective assessment of symptoms that is currently performed when setting the dose of the pump drug Duodopa® developed in Sweden. The new measurement method consists of objective quantification of motor skills and eye motor skills within a cloud-based symptom quantification platform. Corona pandemic forced us to change the approach, but we were still able to collect data to meet the goal of testing the measurement method on five patients.

Expected results and effects

** Denna text är maskinöversatt ** Differences in eye motor skills between medicated patients and healthy controls can be reliably observed with a budget eye follower. Eye followers with better head tracking performance are needed to distinguish between stiffness and dyskinesia in Parkinson´s patients. Smart mobile phone has limited usability for patients with TRS between 0 and -1. However, moderate dyskinesias can be registered.

Planned approach and implementation

** Denna text är maskinöversatt ** The implementation was modified due to coronapandemin. We included more patients than planned (10) to compensate for this, but with limited measurements. The principle of objective symptom quantification by measuring eye and hand motor skills holds for advanced treatments of Parkinson´s disease. More clinical trials with modern mobile eye tracking devices used consistently in titrating patients are required to evaluate the potentialtechnology. Titration strategies based on PK / PD models should also be examined in this context.