E5304, GBA-CONNECT, Kungliga Tekniska Högskolan

Important results from the project

In GBA-Connect project, we developed a platform that mimics interactions between the human gastrointestinal system and the brain via the blood–brain barrier. Our results include an automated instrument, a microfluidic chip, and protocols for generating cells and validating the system’s function. We achieved all objectives except for the automated coupling between the gut and brain systems. The project has also contributed to further dissemination of the technology both within and outside Sweden

Expected long term effects

GBA-Connect has produced important results in making Organ-on-Chip technology more accessible. In the long term, it may enable non-specialized laboratories and companies to use the technology more easily. It can be applied both in drug development and in studies of the effects of chemicals on humans.

Approach and implementation

Cellboxlabs coordinated through regular meetings and project workshops. Discussions regarding specifications and protocol selection worked well. The reporting interval was appropriate. The delay in the technical solution for automated coupling between the gut and brain systems became apparent early in the project. We were then able to focus on delivering protocols for the BBB chip and its characterization. This has greater value for future projects in the field than the automated coupling.