Advanced data analysis and digital twin for continuous production of biologics and vaccines
| Reference number | |
| Coordinator | Lunds universitet - LTH inst för processteknik & tillämpad biovetenskap |
| Funding from Vinnova | SEK 5 000 000 |
| Project duration | October 2022 - September 2025 |
| Status | Ongoing |
| Venture | Strategic innovation programme for process industrial IT and automation – PiiA |
| Call | PiiA: Data analysis in process industrial value chains, spring 2022 |
Important results from the project
The project has demonstrated an integrated complex downstream process for autonomous antibody production with support systems for analysis and buffer as well as built-in technology for advanced digitalisation. This has been done by developing an open architecture of a local control system, called Orbit. A number of digitalisation studies have been carried out. The project´s results have been widely disseminated through a large number of publications and conference contributions.
Expected long term effects
The main goal of the project was to carry out a demonstration illustrating autonomous production of biological pharmaceuticals with integrated automatic quality analysis, buffer management, database and built-in digital technology for monitoring and control. These results, which are based on Swedish technology, have received wide international dissemination, which has had an impact in the field.
Approach and implementation
The project was implemented in three work packages. Work package 1 is focused on conducting physical demonstrations at lab scale of the project´s main results. Work package 2 focused on storing, managing and analyzing advanced sensor data while work package 3 was about studying digital twins. The project has had successful collaborations with three other research projects which has resulted in a large number of results.