Targeting subclinical impairment in patients with early onset Multiple Sclerosis at high Risk of progrEssion

Purpose and goal

RELIABLE aims to improve the prevention of disease worsening from the earliest stages of the disease in Multiple Sclerosis (MS). We will focus on the assessment of sub-clinical deficits in patients without clear neurological dysfunction. Applying personalized interventions may reduce the burden of these deficits, improve the subject quality of life and possibly reduce the chance of future, clinically evident, disability accrual. Adding to that, the overall project will be informed by specific task on stakeholders measures preferences and monitoring of ethical issues.

Expected effects and result

The aim of this pilot study is to assess the subclinical burden of neurological impairments in early Relapsing-Remitting MS patients with no evident neurological disability (Expanded Disability Status Scale, EDSS, score of 2.0 points or less) by applying a comprehensive assessment including comorbidities, lifestyle, imaging, neuropsychological, gait and balance analyses. From these analyses, we will obtain a risk score to predict disease activity. As an added value, we will take into account patient preferences and values to support tailoring the interventions.

Planned approach and implementation

We will apply a comprehensive assessment including commodities, lifestyle, imaging, neuropsychological, gait and balance analyses. We will obtain a risk score to predict disease activity over the short-term (1 year). We will then have a validation cohort the reduction of the rate of patients with evidence of disease activity using a comprehensive and personalized approach. As an added value, we will take into account patient preferences and values to support tailoring the interventions.