Removing chlorinated solvents from drug candidate manufacturing process

Important results from the project

Two new methods have been developed that avoid the use of large amounts of dichloromethane, which is both hazardous to health and a burden on the environment. One of the methods shortens the process by one step, making the process even more cost-effective and less environmentally damaging. The project has provided increased knowledge about how critical contaminants are formed. The project objectives have been achieved and will form an important basis for continued process development.

Expected long term effects

The current process involving dichloromethane would likely not be possible to use for commercial production of vipoglanstat as it is regulated. The project has thus provided critical knowledge in this regard. The results will also contribute to creating a more cost-effective process that poses less risk to factory personnel and has less impact on the environment.

Approach and implementation

Collaboration has worked well and the project has proceeded without major surprises. Rise has carried out all the laboratory work while Gesynta has been responsible for the bulk of the report writing, goal description and compilation of available knowledge. Regular digital meetings have been held where results have been discussed and further work planned. The project start was delayed but was still completed on time (the final report ended up in the holiday period and was therefore postponed).