In-vivo model visualization using synchrotron techniques

Important results from the project

The project has fulfilled the goal of increasing understanding of how structural changes affect the stability and activity of biological drugs. At CoSAXS, MAX IV, complex interactions in solution were analyzed. The goals of establishing methodology and creating new knowledge for future drug development have been achieved. Strike Pharma has strengthened the ability to use synchrotron methods to optimize formulation. New collaborations and strategies have been initiated.

Expected long term effects

The method can become a screening tool to optimize formulations and short development times. The method strengthens Strike Pharmas´s expertise in advanced analytical methods and provides new insights for the design of bispecific antibodies and in the long term can contribute to more efficient development processes in the pharmaceutical industry. The project has laid the foundation for follow-up projects, publications and continued collaboration between industry and academia.

Approach and implementation

The project was conducted in close collaboration between Strike Pharma, Lund University and RISE. Work covered method development, experiments at the CoSAXS beamline (MAX IV) and data analysis. Strike Pharma led sample selection; RISE planned experiments and analyzed results; Lund University provided AF4 expertise and operation. Result interpretation was key to knowledge transfer. The collaboration worked well and built networks that support future initiatives.