Enphasys: accelerated development of reliable oral drug formulations

Important results from the project

** Denna text är maskinöversatt ** Enphasys develops new methods for studies of drug release and absorption after oral administration of complex drug formulations. This project aimed at product optimization of existing equipment and developing a new, small-scale variant of the product. In this work, we have evaluated several types of drug formulations, which have received a positive response from potential customers. With the help of 3D printing, we have also developed a small-scale variant of the product to meet the market´s need for small-scale, fast analysis methods.

Expected long term effects

The small-scale variant that has been developed within the project is adapted for the use of small amounts of drugs and formulations, and preliminary studies show that our prototypes can be combined with artificial membranes. Due to our parallel studies with the larger product, as well as another previously developed small-scale model, we can be sure that the system is compatible with several complex drug formulations. To reach the broader market, however, further development of the prototype is needed to enable studies using cell monolayers.

Approach and implementation

Prototypes of the product have been developed, and validation work has begun. The experiments that have been carried out are focused on ensuring that the absorption membranes remain intact for the desired time. In this stage studies have been performed using a simple drug solution. The next step will thus be to use more complicated formulations. We have also investigated several different other drug formulations, such as amorphous formulations in the large-scale product, which gave us important insights valuable in our continued product optimization.

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