E!9168, 3DPERLAT, Karolinska Institutet
| Reference number | |
| Coordinator | Karolinska Institutet - Karolinska Institutet Inst f fysiologi & farmakologi |
| Funding from Vinnova | SEK 1 890 000 |
| Project duration | April 2026 - March 2028 |
| Status | Ongoing |
| Venture | Eurostars |
Purpose and goal
The aim of this project is to develop and validate a human-relevant in vitro model for studying adipose tissue in obesity. Through 3D bioprinting, biomaterials and microfluidic perfusion, a vascularized, perfused adipose tissue model is created that mimics the human microenvironment. The goal is to establish a robust platform for studying metabolism, inflammation and drug response of human fat tissue.
Expected effects and result
The project is expected to result in a validated, vascularized and perfused 3D model of human adipose tissue with high physiological relevance. The platform will enable long-term culture and analysis of metabolic and inflammatory processes and drug effects. The model improves the understanding of obesity and its mechanisms and strengthens preclinical drug development through more accurate, human-relevant testing platforms.
Planned approach and implementation
The project is implemented in four steps: (1) biomaterial development and design, (2) 3D bioprinting of vascularized adipose tissue, (3) integration into a perfusion bioreactor, and (4) functional validation and drug testing. The work is carried out in close collaboration between partners using iterative optimization and standardized analyses.