Advanced Characterization of RNA-Loaded Lipid Nanoparticles to Enhance Transfection Efficiency
| Reference number | |
| Coordinator | Lunds universitet - Institutionen för processteknik och tillämpad biovetenskap |
| Funding from Vinnova | SEK 1 000 000 |
| Project duration | November 2025 - December 2026 |
| Status | Ongoing |
| Venture | Deepened international collaborations |
| Call | Deepened collaboration with USA, UK and Singapore within Health and Life Science |
Purpose and goal
The project aims to develop new analytical methods to better understand and control lipid nanoparticles used for delivering RNA-based medicines, such as mRNA vaccines. By combining advanced separation and X-ray techniques, we seek to improve knowledge of particle structure and stability, enabling more effective RNA-based therapies in the future.
Expected effects and result
The project is expected to result in new characterization methods and insights for describing and understanding the structure, stability, and RNA loading of lipid nanoparticles. The results will lead to more reliable characterization and better understanding in the development of RNA-based medicines. The collaboration between Lund University and University of Texas at Austin strengthens Swedish research and innovation capacity in pharmaceutical technology.
Planned approach and implementation
The project is carried out in close collaboration between Lund University and the University of Texas at Austin. Lipid nanoparticles are prepared and analyzed using advanced methods such as AF4, SAXS and DENSS, supplemented by electron microscopy. Data are interpreted jointly to develop robust models of the particle structure and loading. The work is divided into experimental studies, method development and knowledge transfer between the parties.