Verification of the use of microneedles as sampling tool for decreased neonatal morbidity
| Reference number | |
| Coordinator | ASCILION AB |
| Funding from Vinnova | SEK 982 000 |
| Project duration | May 2018 - December 2019 |
| Status | Completed |
Important results from the project
The aim of the project was to develop a method based on microneedles for extraction of interstitial fluid (ISF) from the skin - a sampling system that could replace traditional blood tests. We have successfully extracted ISF through microneedles and analyzed the extracted liquid with mass spectrometry. The required amount of liquid has been extracted for reproducible qualitative analysis of phospholipids. Furthermore, the results indicate that the same pattern in lipid composition can be seen between blood and ISF.
Expected long term effects
The results of the project confirm that microneedle extraction of interstitial fluid can work and can be useful in e.g. neonatal care. A sampling technique that reduces the amount of blood samples and thus the need for blood transfusions in neonatal care can eventually reduce mortality in preterm infants. The results indicate that goals are within reach but require further work. The project team is currently discussing a continuation and new studies.
Approach and implementation
The project group consisted of representatives from startups (Ascilion), healthcare (Sahlgrenska University Hospital) and academy (University of Gothenburg). The collaboration has worked well. A delayed delivery of Ascilion´s microneedles meant that the project´s timeframe could not be kept, which is why it was applied for (and granted) an extension. In addition to successfully extraction of interstitial fluid with microneedles, the group has thoroughly characterized the lipid composition of the fluid and published the results in a scientific journal.