Verification of SAXS and SANS techniques for Matrix adjuvant product characterization
| Reference number | |
| Coordinator | RISE Research Institutes of Sweden AB |
| Funding from Vinnova | SEK 1 498 929 |
| Project duration | November 2023 - November 2025 |
| Status | Ongoing |
| Venture | Research infrastructure - utilisation and collaboration |
| Call | Development project for increased industrial utilization of neutron and synchrotron light-based technologies, 2023 |
Important results from the project
All objectives were achieved, demonstrating that small-angle X-ray scattering (SAXS) (MAX IV, CoSAXS, Sweden) and small-angle neutron scattering (SANS) (ISIS, Zoom, UK) are valuable techniques for characterization and development. Novavax strengthened our expertise on large-scale research infrastructures and gained insights into the structure of saponin-based nanoparticles. Additionally, a scientific manuscript and new collaborations on modeling structurally complex systems have been initiated.
Expected long term effects
Long-term the project is expected to significantly increase knowledge of saponin-based nanoparticles and their structure. Detailed characterization enables optimized formulations and tailored properties for specific applications. This reduces uncertainty, shortens lead times, and improves resource efficiency, supporting faster development of new and innovative products.
Approach and implementation
Researchers from Novavax, SAXS and SANS experts from RISE and Chalmers participated in the project. The project included work packages for coordination, sample preparation, analyses, data evaluation, and knowledge dissemination. The overall timeline was followed, though adjustments were needed. SAXS measurements were repeated due to technical issues and sourcing deuterated components took longer than expected. Excellent collaboration and project coordination enabled progress despite challenges.