Personalized Medicine in Acute Infectious Diseases

Purpose and goal

The PERAID project proposes to implement personalized medicine (PM) in severe infectious diseases, such as the large heterogeneous group of sepsis patients and severe soft tissue infections. By virtue of the multifactorial nature of these infections we strongly believe that individualized approaches are required to improve outcome of these patients. The project aims to delineate the host responses at the individual level; thereby, providing the basis for personalized immunotherapy in the field of acute infectious diseases.

Expected results and effects

The project is expected to provide: - A Nordic platform for personalized medicine in infectious diseases. - Concepts and tools for patient stratification in these infections to guide patient stratification and clinical decision making. The advances of PERAID are likely to benefit patient outcome through improved diagnostics and tailored therapies. We envision that the proposed studies will greatly boost personalised medicine in infectious diseases, and a long-term objective is to extend the Nordic platform into the European setting.

Planned approach and implementation

PERAID is composed of 6 highly integrated scientific work packages (WP), of which WP1 represents the core of the project: WP1. Create and manage a Nordic platform for PM in infectious diseases WP2-4. Identify and assess disease signatures/biomarkers for their value in patient stratification and/or as targets for intervention in NSTI and sepsis. WP5. Develop and deploy innovative clinical support tools for patient stratification and bedside decisions suitable for the emergency and intensive care setting. WP6. Perform clinical studies to explore the trial concept.