In-situ analysis of formation and stability of amorphous calcium phosphate for dental applications
| Reference number | |
| Coordinator | Psilox AB |
| Funding from Vinnova | SEK 345 000 |
| Project duration | August 2019 - October 2022 |
| Status | Completed |
| Venture | Research infrastructure - utilisation and collaboration |
| Call | Industrial pilot projects for utilisation of neutron- and photon based techniques at large scale infrastructures - spring 2019 |
| End-of-project report | 2019-02565_Psilox.pdf (pdf, 378 kB) |
Important results from the project
The aim of this project was to study the precipitation and growth of amorphous calcium phosphate particles in-situ, i.e. in a salt solution as a function of time and temperature. The particles can be used as an additive in dental care products to mineralize enamel and dentin. Using the results, we can better understand the precipitation process and thus optimize manufacturing.
Expected long term effects
With the help of the in-situ experiments, we were able to follow the nucleation and development of amorphous structures on an atomic scale, which is near impossible with more conventional methods. The results provide insight into how amorphous materials can be structured, and can contribute to better optimized processes for their manufacturing and stabilization.
Approach and implementation
The in-situ experiments were carried out at P21.2 (DESY) using a specially designed reaction vessel with a window for the X-ray beam. The setup also allowed heating and stirring of the solution, and with rapid acquisition of WAXS and SAXS data, the precipitation and development of amorphous structures could be followed over time and with increasing temperature.