Improved information output from shotgun proteomics by high resolution peptide isoelectric focusing

Reference number
Coordinator Karolinska Institutet - Institutionen för onkologi-patologi
Funding from Vinnova SEK 1 449 800
Project duration December 2011 - December 2018
Status Completed

Purpose and goal

The aim of this project was to develop data analysis methodologies for improved biological interpretation of mass spectrometry protein analysis using high resolution peptide isoelectric focusing (HiRIEF). HiRIEF is a product developed by GE Healthcare (GEH). It has been possible for me to work as a project manager for this at KI and as a guest researcher at GEH by funding from Vinnova and KI, and a good collaboration between KI and GEH.

Expected results and effects

Together with doctoral students and postdocs in the research group at KI, led by Professor Janne Lehtiö, this project has resulted in several publications. Twelve articles in scientific peer-review journals where I am a co-author have been published within the framework of the project 2012 - 2018. HiRIEF developed together with GEH is intended for a clinical market. My experiences from research, industry and clinic during this project will benefit future collaborations and financiation.

Planned approach and implementation

As a project manager, I have been a driving force at the Karolinska Institutet (KI), with research publications as a goal. At GE Healthcare (GEH) in Uppsala, I was a guest researcher, it was a very inspiring period where I had the opportunity to understand opportunities and obstacles with academic collaborations. Back at KI, the focus has been on research and co-financing of research with GEH, which has been successful.

The project description has been provided by the project members themselves and the text has not been looked at by our editors.