Establishing State-of-the-Art Standards for In-Vivo Verification and Adaptive Treatment Planning in Proton Therapy

Purpose and goal

The project aims to develop practical workflows for in vivo verification and adaptive radiotherapy in proton therapy, based on the integration of PET-based monitoring with the Qualyscan system and treatment planning systems. By reducing treatment uncertainties, the project seeks to improve patient safety, treatment precision and clinical effectiveness.

Expected effects and result

The main outcome of the TheraVivo project will be the establishment of clinical and technical approaches for in-vivo verification tools in proton therapy. These include both hardware in teh form of Qualyscan MD and integrated software components for a leading treatment planning system, as well as procedures for clinical implementation. These results will play a pivotal role in improving the safety, accuracy and efficiency in proton therapy treatment for cancer patients.

Planned approach and implementation

The project will be carried out by an international consortium: Terapet is project coordinator and leads hardware development and installation of Qualyscan system. Uppsala University leads the modelling and analysis of PET activation and decay processes. RaySearch Laboratories leads the software development and integration of in-beam PET data into the RayStation treatment planning system. The Skandion Clinic provides clinical environment, access to proton beam and supports validation studies.