E!7991 Fecal-Calprotectin

Purpose and goal

The aim of the project was to develop a rapid turbidimetric assay for faeces calprotectin. The goal is to improve the diagnostics of inflammatory bowel disease while reducing the diagnostic costs. The F-calprotectin test was launched in Europe during the later part of 2015, which means that we have reached the project goal. We are now working on developing additional instrument protocols and the companies are proceeding with work to introduce the assay on the US market/other non-European markets.

Results and expected effects

Buhlmann has launched the new F-calprotectin test in Europe. The assay has a test turnaround time of 10 min and fulfills the criteria defined during the initiation of the project. For details of the assay see: https://www.buhlmannlabs.ch/products-solutions/clinical-chemistry/calprotectin/ There are now available instrument protocols for Roche Cobas c501, Siemens Advia 1650, Advia 1800, Advia 2400, Siemens XPT, Mindray BS200E and Mindray BS380. The project group has also developed a new sampling kit for F-calprotectin that also has been introduced on the market by Buhlmann.

Approach and implementation

The project has been a collaboration between three countries and partners from industry as well as university-hospitals. A kit specification for the final product was defined at the start of the project. This specification has been followed throughout the project and the development of the kit has followed the initial specification without major deviations. The team has worked very well together and we plan to continue this collaboration. As part of this we have asked for project extension to be able to add more instrument applications.