Development of positive allosteric modulators for the treatment of neurodegenerative diseases.

Purpose and goal

The focus of this project is to develop novel drugs that may protect and repair the brain from the damage that occurs in Alzheimer´s disease. The goal has been to identify different substances that work by increasing the effects of growth hormones on nerve cells. We believe that the goal for this period has been achieved because we have developed and improved two different series of promising compounds. These series of compounds are excellent starting points for a future drug for Alzheimer´s disease.

Results and expected effects

The outcomes of the project are new classes of substances that may enhance the effects of growth hormones on nerve cells. The result of the project has been successful and it has also strengthened Swedish entrepreneurship in the life science field as we have worked with three other Swedish companies. The results we have achieved have given us the possibility to discuss with major pharmaceutical companies on a possible future partnership in this project. We expect to continue with the project and further develop the substances that we have now identified.

Approach and implementation

We have during the funding period made use of modern technologies in drug development and have worked with several other companies and universities in Sweden. This is a good example of a process in which the combination of research / development / innovation and collaboration between industry and academia in Sweden has worked well.