Cryoprevention of oral mucositis

Purpose and goal

The primary aim is to study patients with myeloma or lymphoma undergoing autologous SCT, to evaluate whether cooling with Cooral compared with ice cubes/crushed ice or ice pop succeeds in reducing the degree of OM according to the Oral Mucositis Assessment Scale, OMAS total.

Expected results and effects

The results are expected following inclusion of a total of 180 patients

Planned approach and implementation

All measurements, with the exception of the patient’s subjective assessment of the cooling method, will be registered beginning at admission and will continue until discharge or until day +28. Cytostatic infusion generally starts on the day after admission. Grading of OM according to OMAS and WHO is done three times a week. Assessment of the two cooling methods is performed after completion of ice/Cooral cooling in conjunction with cytostatic infusion. Body temperature is registered in the oral cavity in accordance with the department’s routines.