Continuous directed evolution of cell permeable peptides for drug leads and drug delivery
| Reference number | |
| Coordinator | Chalmers Tekniska Högskola AB - Biology and Biological Engineering - Systems and Synthetic Biology |
| Funding from Vinnova | SEK 6 560 170 |
| Project duration | May 2019 - December 2022 |
| Status | Completed |
| Venture | Protein research and process development within the area of Biologics |
| Call | Protein research and process development for biologics - larger projects |
Purpose and goal
A novel drug screening system based on baker´s yeast Saccharomyces cerevisiae was developed. This includes protein-protein interaction based biosensors used for high throughput drug screening.
Expected results and effects
A high-throughput screening pipeline for discovery of novel drugs was established and applied.
Planned approach and implementation
The project was structured into several work packages including the development of synthetic biology tools, high-throughput screenings and data analysis. In case of delays within the project mitigations strategies were followed.