COMPACT

Purpose and goal

The aim of the project is to increase understanding of how complement is involved in cancer by: 1) Elucidating the role of the complement system as a therapeutic objective in cancer treatment by characterizing complement activation patterns in lung & head and neck cancer types 2) Investigating treatment strategies in pre-clinical human models of these cancer types 3) identifying biomarkers for patient stratification as tools in future clinical studies of complement therapy in cancer patients.

Expected effects and result

Development of anti-complement antibody detection kits, specific for reduced Faktor H (FH) and potentially C3, if relevance can be identified. The impact of being able to identify the above-mentioned biomarkers will lead to better treatment of the cancer.

Planned approach and implementation

Production of antibodies for the identified biomarkers within the complement system, and development of, for example, ELISA for detection of the biomarker.