Combating antibiotic resistance using synthetic biology
| Reference number | |
| Coordinator | iGEM Uppsala |
| Funding from Vinnova | SEK 40 000 |
| Project duration | April 2012 - December 2012 |
| Status | Completed |
Purpose and goal
Serious infections caused by antibiotic resistant bacteria are a global healthcare problem. We are developing new methods for targeting the resistance itself - making resistant bacteria sensitive to old antibiotics once again. Working with genes from multi-resistant bacteria isolated at hospitals, we are developing anti-resistance systems using small RNAs to silence resistance genes and transcriptional super-repressors repressing resistance genes and native defence mechanisms.