A novel strategy to prevent wound infections

Purpose and goal

The first part of this project implied different simulations to decide the best geometry to deliver the EF to the wound. The best geometry proposed is reported in Fig. 2. In the second phase of the project we built different prototypes of the pad with different materials for the electrodes. In the third phase of the project, that is still undergoing, the pad was used together with Epiprotect®, a biosynthetic dressing developed by S2Medical AB. To achieve this objective we are using a an in vitro model ofStaphylococcus epidermidisbiofilms on polyvinyl chloride (PVC) material.

Expected results and effects

The design of the electric field, reported in Fig. 2, was chosen since in this case we are able to apply the field and control all its parameters in a precise manner. In the second phase of the project, after interviews with KOLs and literature review, we built prototypes of the pad with different materials for the electrodes. The prototypes are under test by using an in vitro model of ofStaphylococcus epidermidisbiofilms on polyvinyl chloride (PVC) material. This part of the study is still undergoing.

Planned approach and implementation

In this project a pad with parallel stripes connected to a voltage generator has been designed. The pad can deliver a weak electric field to the wound, helping the disruption of the biofilm, if present. Further experiments are needed to verify the effects of the field on the healing of the wound.