Direct Assembly of Synthetic Human Brain Tissue
| Reference number | |
| Coordinator | Lunds universitet - Institutionen för experimentell medicinsk vetenskap |
| Funding from Vinnova | SEK 750 000 |
| Project duration | November 2024 - May 2025 |
| Status | Ongoing |
| Venture | Emerging technology solutions |
| Call | Moonshots through synthetic biology |
Purpose and goal
This project aims to develop a technology for a fast, reproducible and scalable synthesis of functional 3D human brain tissue segments from human, embryonic (hESCs) or induced (hIPSCs) pluripotent stem cells to replicate the complexity of human neural tissue.
Expected effects and result
The resulting 3D system offers new avenues for studying brain physiology, disease mechanisms, drug testing, and provides a powerful platform for personalized medicine and cellular therapies.
Planned approach and implementation
Our technique combines multiple synthetic biology tools, including transcription factor-controlled differentiation, gene regulatory circuitry, CRISPR technology, and site-specific recombination