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Ceramic drug carrier for tamper resistant oral drug delivery

Reference number
Coordinator Emplicure AB (publ)
Funding from Vinnova SEK 1 000 000
Project duration June 2023 - April 2025
Status Completed
Venture Competence centre

Important results from the project

The project has developed and verified a novel formulation and granulation method for drug-loaded ceramic granules with extended controlled release and high tamper resistance in aim to prevent abuse and overdose of prescription opioids. Release tests and bioavailability models demonstrate improved controlled release of two model substances compared to existing commercial tablets. The results support further development towards clinical application.

Expected long term effects

The project is expected to contribute in the long term to safer drug treatments by reducing the risk of opioid abuse, and to enable individualized dosing for pain relief. The development of bioceramic carrier systems can lead to new medical devices, strengthened innovation and cutting-edge expertise. The project also supports academic knowledge building through postgraduate education, which benefits both universities and industry over time.

Approach and implementation

The project was carried out in several phases where formulation and manufacturing were followed by testing and optimization of the mechanical properties, geometry and drug release with model substances. Drug release was further validated with in vitro bioavailability methods to better reflect bioavailability across the mucosa to achieve the desired product profile with both controlled release and abuse deterrent properties. The collaboration within the project worked very well.

The project description has been provided by the project members themselves and the text has not been looked at by our editors.

Last updated 4 July 2025

Reference number 2023-01177