Ancestral scaffold antigens as a resilient technology for fast response to viruses and pandemics
| Reference number | |
| Coordinator | Kungliga Tekniska Högskolan - Skolan f kemi bioteknologi & hälsa Inst f fiber- & polymerteknologi |
| Funding from Vinnova | SEK 2 000 000 |
| Project duration | July 2024 - June 2025 |
| Status | Ongoing |
| Venture | Emerging technology solutions |
| Call | Emerging technology solutions within quantum technology and synthetic biology 2024 |
Purpose and goal
The main goal of the project is to validate a unique data-driven approach based on the generation of stable ancestral antigen building blocks (AnSAs) to combat disease. We will validate AnSAs as a resilient synthetic biology platform to combat pathogens and enable rapid response against new betacoronaviruses and variants.
Expected effects and result
A "reverse-forward" protein engineering technology that takes a step towards universal vaccines and can be generally applicable to fight various emerging viruses and respond to future pandemics. Our strategy is compatible with both protein- and mRNA-based vaccines.
Planned approach and implementation
Validate (TRL3) AnSAs as a versatile synthetic biology platform to combat pathogens and enable rapid response against new viruses and variants. This will be achieved by bridging sequence-based protein design (KTH, Syrén) with immunology (KI, Pan-Hammarström).