Reduced risk for thrombosis using noble metal coated stents (NOBLE STENT)

Important results from the project

The purpose of the project was to coat stents with Bactiguard´s technology and then be able to show, both in vitro and in vivo, reduction of coagulation, platelet activation and protein deposition. The goal of the project is to obtain a coating on stents that reduces the activation of coagulation factors and thereby thrombosis. In this way, we hope to reduce the amount of antiplatelet drugs that patients with these stents need to take. The project reached the goal within the planned time.

Expected long term effects

The final results from our in vitro studies show that Bactiguard´s coatings significantly reduce coagulation factor activation, platelet aggregation and fibrin deposition. The results from the in vivo studies show that the coating reduces the thrombus volume on coated stents compared to control stents.

Approach and implementation

The project was carried out in 3 WP. WP1 selected the type of stent, developed the coating, developed the process of reassembling the stent on the catheter. WP2 performed in vitro studies, where coated and uncoated stents or prototype materials were exposed to human blood and pig blood where different coagulation parameters and platelet activation were measured. WP3 conducted in vivo studies in which Bactiguard´s coated stents were compared side-by-side with uncoated stents in a pig model. Analyzes were performed with cone beam CT angiography, 3D analysis and biochemical analysis.