EFFICIENT PRODUCTION AND DEVELOPMENT OF NOVEL BIOLOGICS INSPIRED BY HOW SPIDERS MAKE SILK

Purpose and goal

** Denna text är maskinöversatt ** The project idea is based on the fact that the N-terminal domain from spidroins, NT, holds the aggregation-prone spidroins in solution. The project has delivered results under all the points described in the original proposal and is the basis for two doctoral dissertations, 11 published articles, and four articles under review or in manuscript form. The only goal in the proposal that we have not yet met is to evaluate NT´s potential for production in mammalian cells. However, we evaluated NT for production in yeast cells with good results.

Expected results and effects

** Denna text är maskinöversatt ** The scientific results have mainly been achieved. The NT method works and we have distributed plasmids to dozens of research groups. We have succeeded in broadening the use of the NT method by identifying another NT variant in addition to the one described in the proposal. As far as cooperation aspects are concerned, they have also fallen out well. Of the 11 published articles attached, three have authors from two partners, four articles have authors from three partners and one article has authors from four of the five collaborating partners.

Planned approach and implementation

** Denna text är maskinöversatt ** The project had a clear research profile and the three partners who are active in academic research have collaborated extensively and intensively with, at certain times, mostly daily or at least weekly meetings. We have also had regular and fruitful contacts and meetings with the two commercial partners. The project has resulted in all partners intending to continue the collaboration, and we are very grateful to Vinnova´s support that made this possible.