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A biooptical method for microcirculation assessment as an early predictor of cardiovascular disease

Reference number
Coordinator Linköpings universitet - Institutionen för medicinsk teknik (IMT)
Funding from Vinnova SEK 2 000 000
Project duration September 2016 - August 2018
Status Completed

Purpose and goal

The aim is to further develop a system for comprehensive microcirculation assessment by measuring blood flow, blood concentration and oxygen saturation in physiologically relevant units. Measurement accuracy is validated using advanced optical phantoms. The usability is evaluated for nurseled clinical research measurements. The system will be used in clinical research to study the relationship to cardiovascular diseases within the national SCAPIS study (Swedish Cardiopulmonary bioImage Study; Heart-Lung foundation). Perimed AB will bring the system to a research market.

Expected results and effects

Measurement accuracy is good, and the systems is user friendly when operated by health care staff. The measurement failure rate is very low. The software gives valuable feedback on signal quality and the data analysis. We have performed a very large and unique study on the relationship to cardiovascular disease. Several scientific articles have been published and popular science presentations have been given. The system is marketed by Perimed and several units have been sold.

Planned approach and implementation

We have used two systems in the project, one for studies of measurement accuracy in collaboration with the world-leading Beckman Laser Institute, CA, USA. In parallel, we have undertaken an extensive clinical study within the national SCAPIS study. One full time nurse has performed data recording for three years. The company Perimed and the researchers have supported the system and the measurements. The data is analyzed in several clinical studies. Perimed aims to further develop the analysis software using machine learning for improved robustness.

External links

The project description has been provided by the project members themselves and the text has not been looked at by our editors.

Last updated 8 January 2019

Reference number 2016-02211

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